With Jane Brown, Psy.D.*
Traumatic brain injury (TBI) afflicts people of all ages and genders, and the severity of injury ranges from concussion to more severe injury, with wide-ranging, variable symptomology and outcomes. Treatment options have generally been lacking for the early syndromes and late presentations of TBI and the associated neurobehavioral and neuropsychiatric symptoms. With increasing recognition of the contribution of neuro-inflammation as a major mediating factor in animal models and human translational studies, there is the prospect for improving the understanding of the mechanisms of TBI, and developing therapeutic strategies to improve the outcomes of the millions of people affected each year.