Neurologic hereditary metabolic disorders (NHMD), while difficult to recognize at birth, lead to unmistakable neurological symptoms and signs that become clinically evident in the neonatal period, through early and late infancy into childhood, each with a specific biochemical, molecular or cytogenetic defect, and unique genetic inheritance pattern.
The first stage in the journey of arriving at a correct diagnosis is to be in touch with your symptoms and to convey them accurately to the physicians you see. I recommend arriving to appointments with a written narrative of the temporal progression of symptoms replete with dates and recollections of when certain symptoms emerged and describe how they progressed over time.
Although the subject has been debated for decades, it is still unclear whether all psychotherapies are equally efficacious. Meta-analyses of over 50 studies analyzing seven major types of psychological treatment for mild to moderate adult depression (cognitive behavioral therapy [CBT], nondirective supportive treatment, behavioral activation treatment [BAT], psychodynamic treatment, problem-solving therapy, interpersonal psychotherapy, and social skills training) showed no striking differences, with the exception of interpersonal psychotherapy, that was somewhat more efficacious, and nondirective supportive treatment that was somewhat less efficacious than the others. Mindfulness-based therapy in which attention is sequentially directed throughout the body, has gained increasing appeal as a modality to reduce stress, anxiety, and depression.
Generalized anxiety disorder (GAD) is a chronic and disabling disorder with a low rate of full remission. It has been commonly assumed that pathologic anxiety is a continuing chronic course of early-onset illness, a perspective that is changing with current research.
This mood disorder is characterized by alternating states of major depression and mania characterized by low energy, impaired motivation and need for sleep, feelings of extreme sadness, failure, worthlessness, and hopelessness; while mania is accompanied by elevations in energy and mood, with racing thoughts and speech, decreased need for sleep, grandiosity, and enhanced risk taking.
Just a few years after the most recent World Health Organization report on the global burden of disease, mental health has remained a low priority in most low-income and middle-income countries. Such nations instead prioritize the control and eradication of infectious, reproductive, maternal, and child health diseases.