Page 273 - The Vasculitides, Volume 1: General Considerations and Systemic Vasculitis
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Systemic Vasculitis and the Lung 247
not well understood but may relate to oxidative bursts of mononuclear inflammatory cells
triggered by the ANCA, along with damage resulting from recurrent or chronic alveolar
hemorrhage [25-27]. The mortality rate of pulmonary fibrosis with anti-MPO P-ANCA is
similar to that of idiopathic pulmonary fibrosis and worse than ILD occurring with collagen
vascular diseases without anti-MPO P-ANCA [28].
Figure 3. Multiple plain lung nodules in a patient with granulomatosis with polyangiitis (axial CT
images).
Figure 4. Large cavitation nodule in a patient with granulomatosis with polyangiitis (left: chest X-ray
showing hydro-aeric cavity; right: same nodule on frontal CT scan, upper and aeric part of the nodule).
Figure 5. Patchy lung alveolar interstitial infiltrates in a patient with eosinophilic granulomatosis with
polyangiitis (frontal and axial CT images).
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