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Nomenclature and Pathologic Features of Vasculitides 141

Conclusion

Many factors must be taken into consideration in rendering an accurate and precise
clinical diagnosis of vasculitis in a given patient, such as the clinical signs and symptoms,
results of laboratory tests, and the observed histopathology of involved organ tissue. The most
important aspects include the types of vessels affected, as for example arteries or venules; the
pathologic features of the inflammatory process such as leukocytoclastic inflammation versus
granulomatous inflammation; immunopathologic features such as IgA-dominant deposits or
paucity of immunoglobulin in vessel walls; serologic findings such as cryoglobulins or
ANCA; associated systemic disease such as RA or SLE; and proximate etiologies such as
HCV and propylthiouracil; as well as, the distribution of lesions to affected organ systems
such as the lungs versus the gut; and any accompanying extravascular lesions such as
necrotizing granulomatosis or aphthous ulcers, and other factors.

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