Page 151 - The Vasculitides, Volume 1: General Considerations and Systemic Vasculitis
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Nomenclature and Pathologic Features of Vasculitides 127
irregular accumulation of fibrin in areas of necrosis is called fibrinoid necrosis and is deeply
eosinophilic in hematoxylin and eosin (H&E) stained sections (Figure 3), and red
(fuchsinophilic) in Masson trichrome stained sections (Figure 4A).
Figure 2. Multinucleated giant cells in the inflamed media of the aorta (aortitis) in a patient with giant
cell arteritis (H&E stain).
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Figure 3. A (left): Irregular accumulation of eosinophilic fibrin in areas of fibrinoid necrosis with
adjacent neutrophil-rich leukocyte infiltration in a medium artery in a patient with polyarteritis nodosa.
B (right): Interlobar artery in a patient with Kawasaki disease with transmural inflammation including
intimal arteritis, medial inflammation with dehiscence of medial cells, adventitial inflammation and a
small focus of intimal fibrinoid necrosis (arrow).
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