Page 118 - The Vasculitides, Volume 1: General Considerations and Systemic Vasculitis

94 Alan D. Salama and Mark A. Little

antibody-associated vasculitis: the role of Treg cells and tryptophan degradation.
Arthritis Rheum. 2010; 62:1539-1548.
[18] Little, M. A., Smyth, L., Salama, A. D., et al. Experimental autoimmune vasculitis: an
animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic
vasculitis. Am. J. Pathol. 2009; 174:1212-1220.
[19] Little, M. A., Smyth, C. L., Yadav, R., et al. Antineutrophil cytoplasm antibodies
directed against myeloperoxidase augment leukocyte-microvascular interactions in
vivo. Blood 2005; 106:2050-2058.
[20] Aitman, T. J., Dong, R., Vyse, T. J., et al. Copy number polymorphism in Fcgr3
predisposes to glomerulonephritis in rats and humans. Nature 2006; 439:851-855.
[21] McDaid, J. P., Tanna, A., Ghangal, G., et al. The role of quantitative trait loci(QTL) in
the pathogenesis of experimental autoimmune vasculitis. Presse Medicale 2013; 42:
688.
[22] Roth, A. J., Ooi, J. D., Hess, J. J., et al. Epitope specificity determines pathogenicity
and detectability in ANCA-associated vasculitis. J. Clin. Invest. 2013; 123:1773-1783.
[23] Van der Geld, Y. M., Hellmark, T., Selga, D., et al. Rats and mice immunised with
chimeric human/mouse proteinase 3 produce autoantibodies to mouse Pr3 and rat
granulocytes. Ann. Rheum. Dis. 2007; 66:1679-1682.
[24] Pfister, H., Ollert, M., Fröhlich, L. F., et al. Antineutrophil cytoplasmic autoantibodies
against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in
vivo. Blood 2004; 104:1411-1418.
[25] Primo, V. C., Marusic, S., Franklin, C. C., et al. Anti-PR3 immune responses induce
segmental and necrotizing glomerulonephritis. Clin. Exp. Immunol. 2010; 159:327-337.
[26] Relle, M., et al. PR3 antibodies do not induce renal pathology in a novel PR3-
humanized mouse model for Wegener's granulomatosis. Rheumatol. Int. 2013; 33:613-
622.
[27] Little, M. A., Al-Ani, B., Ren, S., et al. Anti-proteinase 3 anti-neutrophil cytoplasm
autoantibodies recapitulate systemic vasculitis in mice with a humanized immune
system. PLoS One 2012; 7:e28626.

Complimentary Contributor Copy